Mojo unleashes a curse on Townsville that turns everyone into dogs, including the Powerpuff Girls! Luckily, they manage to sniff out a solution.
Vile villain Roach Coach has a plan to infest Townsville with an army of cockroaches! That is, until the Girls force him to bug off.
The Amoeba Boys' ill-conceived plan to stand in the rain all night leaves them with a nasty virus that's really something to sneeze at.
Buttercup falls for the leader of the Gangreen Gang. But when the gang exploits her infatuation, she shows them the real meaning of the word "crush.
The Boogie Man creates perpetual night by launching a huge disco ball to block out the sun. So the Powerpuff Girls plot to crash the ball.
The Gangreen Gang gets ahold of the Powerpuff Girls' Hotline and makes crank calls, sending the Powerpuff Girls on a wild goose chase all over town.
Major Man, a perfect new superhero in town, cuts in on the girls' turf. But the girls prove they're still integral to saving the day.
During a heat wave, Blossom discovers that she has a new power: ice breath. But when she doesn't use her new gift wisely, she gets a chilly reception.
Bubbles is tired of people dismissing her as more sugar than spice. So she sets out to take everyone by surprise -- even Mojo Jojo.
Fuzzy Lumpkins throws his hat into the mayoral ring and claims a surprise victory. So now it's up to the mayor and the girls to get him out of office.
The Powerpuff Girls lose their baseball in Mojo's house, giving him the perfect opportunity to destroy the pesky superheroines.
Mojo Jojo creates the ultimate weapons to use against the Powerpuff Girls: boy equivalents! Enter Butch, Boomer and Brick... the Rowdyruff Boys.
Worried about his little girls' safety, the Professor creates Powerpuff Dynamo, a state-of-the-art protection system, to help them in battle.
Bratty little Princess comes to town and wants to be a Powerpuff Girl. But when she doesn't get what she wants, the girls have to pay.
A fan of the Powerpuff Girls has collected every bit of Powerpuff stuff available. But his collection will be complete with just three more items.
It's the girls' birthday, and some presents have arrived from their main enemies. Can they destroy these evil gifts without destroying their party?
The Sandman would like a little rest, so he puts the world to sleep. But the girls must battle him in his dreams to get things back to normal.
When Broccoli Aliens from space invade Townsville, it's up to the Powerpuff Girls and all the children of Townsville to take a bite out of crime.
The girls save Big Billy's life, and he's forever indebted. But how will they get this bumbling fellow out of their way so they can save the world?
The girls are exhausted at school from saving Townsville past their bedtime. What will happen to their town when the girls are put on a curfew?
Princess hires Mojo to devise a plan to destroy the girls, who are shocked when they find that Princess has powers equal to their own.
Mojo observes that everyone is avoiding little Harry Pitt because he has "cooties." So he concocts a plan, using this cootie-covered boy as bait.
It's raining, and there's no crime or villainy afoot. So the girls must stay inside and come up with their own Powerpuff adventure.
The girls decide they need some help fighting crime, so they create another Powerpuff Girl. But there's something's a little off about her.
When the children of Pokey Oaks become envious of the Powerpuff Girls' superpowers, a mysterious figure offers them Chemical X.
When the girls decide to have an all-girl slumber party, a villain in a not-so-clever disguise decides to crash the fun.